Histone H2A.X antibody

GeneTex

Histone H2A.X antibody

9

Western Blot, ImmunoHistoChemistry

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

h2ax

H2A.X variant histone

H2A histone family, member X; H2A.; H2A.X; H2a/x; h2af; h2afx; histone H2A.x; histone H2AX; zgc:56329

Rabbit

IgG

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.

Fish, Zebra Fish

2°C to 8°C,-20°C or -80°C

12352203