Histone H2A.X antibody
GTX127343
ApplicationsWestern Blot, ImmunoHistoChemistry
Product group Antibodies
ReactivityFish, Zebra Fish
Targeth2ax
Overview
- SupplierGeneTex
- Product NameHistone H2A.X antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. IHC-Wm: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsWestern Blot, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID394048
- Target nameh2ax
- Target descriptionH2A.X variant histone
- Target synonymsH2A histone family, member X; H2A.; H2A.X; H2a/x; h2af; h2afx; histone H2A.x; histone H2AX; zgc:56329
- HostRabbit
- IsotypeIgG
- Protein IDQ7ZUY3
- Protein NameHistone H2AX
- Scientific DescriptionVariant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
- ReactivityFish, Zebra Fish
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Aging Triggers H3K27 Trimethylation Hoarding in the Chromatin of Nothobranchius furzeri Skeletal Muscle. Cencioni C et al., 2019 Sep 28, CellsRead more