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ProductsBack/Histone H2A.XS139ph (phospho Ser139) antibody [3F2] - Orthogonal Validated
IHC-P analysis of postnatal mouse (PN19) lung sections using GTX80694 Histone H2A.XS139ph (phospho Ser139) antibody [3F2]. Increased staining intensity was observed in a genetic mouse model with DNA damage in airway cells. Antigen retrieval : heat induced epitope retrieval (HIER) method with sodium citrate buffer (pH 6.0) Fixation : 4% Paraformaldehyde Dilution : 1:400
IHC-P analysis of postnatal mouse (PN19) lung sections using GTX80694 Histone H2A.XS139ph (phospho Ser139) antibody [3F2]. Increased staining intensity was observed in a genetic mouse model with DNA damage in airway cells. Antigen retrieval : heat induced epitope retrieval (HIER) method with sodium citrate buffer (pH 6.0) Fixation : 4% Paraformaldehyde Dilution : 1:400
IHC-P analysis of postnatal mouse (PN19) lung sections using GTX80694 Histone H2A.XS139ph (phospho Ser139) antibody [3F2]. Increased staining intensity was observed in a genetic mouse model with DNA damage in airway cells. Antigen retrieval : heat induced epitope retrieval (HIER) method with sodium citrate buffer (pH 6.0) Fixation : 4% Paraformaldehyde Dilution : 1:400

Histone H2A.XS139ph (phospho Ser139) antibody [3F2] - Orthogonal Validated

Research Use Only
GTX80694
GeneTex
ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
ReactivityBovine, Human, Mouse
TargetH2AX
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Overview

  • Supplier
    GeneTex
  • Product Name
    Histone H2A.XS139ph (phospho Ser139) antibody [3F2] - Orthogonal Validated
  • Delivery Days Customer
    9
  • Antibody Specificity
    The immunogen of this antibody is a synthetic peptide sequence surrounding phosphorylated Ser140. Some references call Ser140, by the name Ser139.
  • Applications
    Flow Cytometry, ImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    3F2
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID3014
  • Target name
    H2AX
  • Target description
    H2A.X variant histone
  • Target synonyms
    H2A histone family member X; H2A.X; H2A/X; H2AFX; H2AX histone; histone H2A.x; histone H2AX
  • Host
    Mouse
  • Isotype
    IgG1
  • Modification Type
    Phosphorylated
  • Scientific Description
    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-independent histone that is a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Oct 2015]
  • Reactivity
    Bovine, Human, Mouse
  • Storage Instruction
    2°C to 8°C,-20°C or -80°C
  • UNSPSC
    12352203

References

  • CYT-Rx20 inhibits ovarian cancer cells in vitro and in vivo through oxidative stress-induced DNA damage and cell apoptosis. Wang YY et al., 2017 Jun, Cancer Chemother Pharmacol
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  • Synthetic beta-nitrostyrene derivative CYT-Rx20 as inhibitor of oral cancer cell proliferation and tumor growth through glutathione suppression and reactive oxygen species induction. Wang YY et al., 2017 Jun, Head Neck
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  • Curcumin causes DNA damage and affects associated protein expression in HeLa human cervical cancer cells. Shang HS et al., 2016 Oct, Oncol Rep
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  • Direct activation of ATM by resveratrol under oxidizing conditions. Lee JH et al., 2014, PLoS One
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  • Histone deacetylase inhibitors selectively target homology dependent DNA repair defective cells and elevate non-homologous endjoining activity. Smith S et al., 2014, PLoS One
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  • High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Fox JT et al., 2012 Apr 3, Proc Natl Acad Sci U S A
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  • Induction of reactive oxygen species by human T-cell leukemia virus type 1 tax correlates with DNA damage and expression of cellular senescence marker. Kinjo T et al., 2010 May, J Virol
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