Histone H2A.XS139ph (phospho Ser139) antibody
GTX127342
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Zebra Fish
Targeth2ax
Overview
- SupplierGeneTex
- Product NameHistone H2A.XS139ph (phospho Ser139) antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. IHC-P: 1:100-1:2000. IHC-Wm: 1:100-1:500. IHC: 1:100-1:2000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.47 mg/ml
- ConjugateUnconjugated
- Gene ID394048
- Target nameh2ax
- Target descriptionH2A.X variant histone
- Target synonymsh2afx, zgc:56329, histone H2AX, H2A histone family, member X, H2A.X, H2a/x, histone H2A.x
- HostRabbit
- IsotypeIgG
- Protein IDQ7ZUY3
- Protein NameHistone H2AX
- Scientific DescriptionVariant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
- ReactivityHuman, Zebra Fish
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Cacialli P, Dogan S, Linnerz T, et al. Minichromosome maintenance protein 10 (mcm10) regulates hematopoietic stem cell emergence in the zebrafish embryo. Stem Cell Reports. 2023,18(7):1534-1546. doi: 10.1016/j.stemcr.2023.05.022Read this paper
- El Maï M, Bird M, Allouche A, et al. Gut-specific telomerase expression counteracts systemic aging in telomerase-deficient zebrafish. Nat Aging. 2023,3(5):567-584. doi: 10.1038/s43587-023-00401-5Read this paper
- Song J, Ma J, Liu X, et al. The MRN complex maintains the biliary-derived hepatocytes in liver regeneration through ATR-Chk1 pathway. NPJ Regen Med. 2023,8(1):20. doi: 10.1038/s41536-023-00294-3Read this paper
- Tian Y, Wang W, Lautrup S, et al. WRN promotes bone development and growth by unwinding SHOX-G-quadruplexes via its helicase activity in Werner Syndrome. Nat Commun. 2022,13(1):5456. doi: 10.1038/s41467-022-33012-6Read this paper
- Ma J, Shao X, Geng F, et al. Ercc2/Xpd deficiency results in failure of digestive organ growth in zebrafish with elevated nucleolar stress. iScience. 2022,25(9):104957. doi: 10.1016/j.isci.2022.104957Read this paper
- Xie H, Wang X, Jin M, et al. Cilia regulate meiotic recombination in zebrafish. J Mol Cell Biol. 2022,14(7). doi: 10.1093/jmcb/mjac049Read this paper
- Babu S, Takeuchi Y, Masai I. Banp regulates DNA damage response and chromosome segregation during the cell cycle in zebrafish retina. Elife. 2022,11. doi: 10.7554/eLife.74611Read this paper
- Ellis PS, Martins RR, Thompson EJ, et al. A subset of gut leukocytes has telomerase-dependent "hyper-long" telomeres and require telomerase for function in zebrafish. Immun Ageing. 2022,19(1):31. doi: 10.1186/s12979-022-00287-8Read this paper
- Lai JKH, Toh PJY, Cognart HA, et al. DNA-damage induced cell death in yap1;wwtr1 mutant epidermal basal cells. Elife. 2022,11. doi: 10.7554/eLife.72302Read this paper
- Annus T, Müller D, Jezsó B, et al. Bloom syndrome helicase contributes to germ line development and longevity in zebrafish. Cell Death Dis. 2022,13(4):363. doi: 10.1038/s41419-022-04815-8Read this paper
Datasheet
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