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ProductsBack/Histone H2A.XS139ph (phospho Ser139) antibody

Histone H2A.XS139ph (phospho Ser139) antibody

GTX127342
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Zebra Fish
Targeth2ax
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Overview

  • Supplier
    GeneTex
  • Product Name
    Histone H2A.XS139ph (phospho Ser139) antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. IHC-P: 1:100-1:2000. IHC-Wm: 1:100-1:500. IHC: 1:100-1:2000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.47 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID394048
  • Target name
    h2ax
  • Target description
    H2A.X variant histone
  • Target synonyms
    H2A histone family, member X; H2A.; H2A.X; H2a/x; h2af; h2afx; histone H2A.x; histone H2AX; zgc:56329
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ7ZUY3
  • Protein Name
    Histone H2AX
  • Scientific Description
    Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
  • Reactivity
    Human, Zebra Fish
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Minichromosome maintenance protein 10 (mcm10) regulates hematopoietic stem cell emergence in the zebrafish embryo.
    Read more
  • Gut-specific telomerase expression counteracts systemic aging in telomerase-deficient zebrafish.
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  • The MRN complex maintains the biliary-derived hepatocytes in liver regeneration through ATR-Chk1 pathway.
    Read more
  • WRN promotes bone development and growth by unwinding SHOX-G-quadruplexes via its helicase activity in Werner Syndrome.
    Read more
  • Ercc2/Xpd deficiency results in failure of digestive organ growth in zebrafish with elevated nucleolar stress.
    Read more
  • Cilia regulate meiotic recombination in zebrafish.
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  • Banp regulates DNA damage response and chromosome segregation during the cell cycle in zebrafish retina.
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  • A subset of gut leukocytes has telomerase-dependent hyper-long telomeres and require telomerase for function in zebrafish.
    Read more
  • DNA-damage induced cell death in yap1;wwtr1 mutant epidermal basal cells. Lai JKH et al., 2022 May 30, Elife
    Read more
  • Bloom syndrome helicase contributes to germ line development and longevity in zebrafish. Annus T et al., 2022 Apr 18, Cell Death Dis
    Read more