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ProductsBack/Histone H2A.XS139ph (phospho Ser139) antibody

Histone H2A.XS139ph (phospho Ser139) antibody

Research Use Only
GTX127342
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Zebra Fish
Targeth2ax
Price on request
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Overview

  • Supplier
    GeneTex
  • Product Name
    Histone H2A.XS139ph (phospho Ser139) antibody
  • Delivery Days Customer
    9
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID394048
  • Target name
    h2ax
  • Target description
    H2A.X variant histone
  • Target synonyms
    H2A histone family, member X; H2A.; H2A.X; H2a/x; h2af; h2afx; histone H2A.x; histone H2AX; zgc:56329
  • Host
    Rabbit
  • Isotype
    IgG
  • Modification Type
    Phosphorylated
  • Scientific Description
    Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
  • Reactivity
    Human, Zebra Fish
  • Storage Instruction
    2°C to 8°C,-20°C or -80°C
  • UNSPSC
    12352203

References

  • DNA-damage induced cell death in yap1;wwtr1 mutant epidermal basal cells. Lai JKH et al., 2022 May 30, Elife
    Read more
  • Bloom syndrome helicase contributes to germ line development and longevity in zebrafish. Annus T et al., 2022 Apr 18, Cell Death Dis
    Read more
  • Pathway-specific effects of ADSL deficiency on neurodevelopment. Dutto I et al., 2022 Feb 8, Elife
    Read more
  • DTYMK is essential for genome integrity and neuronal survival. Vanoevelen JM et al., 2022 Feb, Acta Neuropathol
    Read more
  • NAMPT-derived NAD+ fuels PARP1 to promote skin inflammation through parthanatos cell death. Martinez-Morcillo FJ et al., 2021 Nov, PLoS Biol
    Read more
  • Reduction of oxidative stress suppresses poly-GR-mediated toxicity in zebrafish embryos. Riemslagh FW et al., 2021 Nov 1, Dis Model Mech
    Read more
  • The killifish visual system as an in vivo model to study brain aging and rejuvenation. Vanhunsel S et al., 2021 Aug 17, NPJ Aging Mech Dis
    Read more
  • Tdp1 protects from topoisomerase 1-mediated chromosomal breaks in adult zebrafish but is dispensable during larval development. Zaksauskaite R et al., 2021 Jan, Sci Adv
    Read more
  • Anti-Proliferative and Pro-Apoptotic Effects of Short-Term Inhibition of Telomerase In Vivo and in Human Malignant B Cells Xenografted in Zebrafish. Giunco S et al., 2020 Jul 25, Cancers (Basel)
    Read more
  • Opposing p53 and mTOR/AKT promote an in vivo switch from apoptosis to senescence upon telomere shortening in zebrafish. El Mai M et al., 2020 May 19, Elife
    Read more