HIV-1 protease-IN-8

MedChem Express

HIV-1 protease-IN-8

10

Research Use Only

C25H35N3O5S

489.63

HIV-1 protease-IN-8 (compound 34b) is a potent HIV-1 protease inhibitor with an IC50 value of 0.32 nM. HIV-1 protease-IN-8 displays IC50s of 0.29 microM and 1.90 microM for wild-type HIV-1 (HIV-1NL4-3) and drug-resistant variant (HIV-1MDR), respectively. HIV-1 protease-IN-8 displays robust antiviral activity against both wild-type HIV-1 and drug-resistant variant[1].

O=C(N[C@@H](CC1=CC=CC=C1)[C@H](O)CN(CC(C)C)S(=O)(C2=CC=C(C=C2)O)=O)[C@@H]3CCNC3

12352200