HJC-0123 [1430420-02-2]

TargetMol Chemicals

HJC-0123 [1430420-02-2]

72

Chemical

Research Use Only

HJC-0123

C24H16N2O3S

412.46

Downregulate phosphorylation of STAT3, increase the expression of cleaved caspase-3, inhibit cell cycle progression and promote apoptosis in breast and pancreatic cancer cells with low micromolar to nanomolar IC50 values. Furthermore, HJC-0123 significantly suppressed estrogen receptor (ER)-negative breast cancer MDA-MB-231 xenograft tumor growth in vivo (p.o.), indicating its great potential as an efficacious and orally bioavailable drug candidate for human cancer therapy.

3 years

C(NC=1C=C2C(=CC1)C=CS2(=O)=O)(=O)C=3C4=C(N=C(C3)C5=CC=CC=C5)C=CC=C4

-20°C

12352200