HLA-ABC Antibody (MHC I)

Biorbyt

HLA-ABC Antibody (MHC I)

10

ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT IHC-P

Research Use Only

Monoclonal

MHC-I/8147R

Unconjugated

HLA-A

major histocompatibility complex, class I, A

HLA class I histocompatibility antigen, A alpha chain; HLA class I histocompatibility antigen, A-1 alpha chain; HLAA; leukocyte antigen class I-A; MHC class I antigen HLA-A heavy chain

Rabbit

IgG

HLA class I histocompatibility antigen, B-7 alpha chain

Major Histocompatibility Complex (MHC) is a genetic region on chromosomes composed of tightly linked highly polymorphic gene loci that encode cell surface specific proteins, depending on the structure and function of genes and coding products. We divide MHC into class I (telomeric), class II (centromeric) and class III gene regions. Endogenous antigen presentation is presented by the major histocompatibility complex I (MHC I ) pathway. Intracytoplasmic proteins are decomposed into peptides during protease degradation, which in turn are delivered by HSP41 and HSP90 proteins to TAP on the membrane. MHC I is widely distributed on the surface of almost all nucleated cells, including spleen, lymph nodes and thymus lymphocytes in normal tissues. It is also expressed in skin, lung, kidney, liver and heart tissues. It is also widely expressed in tumor tissues. MHC molecular typing is related to the matching of organ transplantation and bone marrow transplantation, as well as a variety of autoimmune diseases.

Human

-20°C

12352203