HLA DP/DQ/DR mAb (IVA12), InVivoPure+
AK3601P+
ApplicationsNeutralisation/Blocking
Product group Antibodies
ReactivityHuman
Product AK3601P+ is not available
Product not available
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Overview
- SupplierInVivo Biotech
- Product NameHLA DP/DQ/DR mAb (IVA12), InVivoPure+
- Delivery Days Customer5
- ApplicationsNeutralisation/Blocking
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDIVA12
- Concentration1 mg/ml
- Estimated Purity>=95%
- FormulationLiquid
- HostMouse
- IsotypeIgG1
- Scientific DescriptionThe clone IVA12 recognizes the shared epitopes of human leukocyte antigen (HLA) class II molecules HLA-DP, HLA-DQ and HLA-DR heterodimeric cell surface glycoproteins comprised of an alpha (heavy) chain and a beta (light) chain. They are expressed on B cells, activated T cells, monocytes/macrophages, dendritic cells, and other non-professional antigen presenting cells (APCs). HLA-Class II expressing APCs specifically present antigens recognized by TCR/CD3 complex of CD4+ T cells. Reactive microglia and perivascular cells in multiple sclerosis lesions express all three types of HLA-Class II molecules, whereas microglia in the normal CNS express HLA-DR only.
- ReactivityHuman
- UNSPSC12352203