HLA DP/DQ/DR mAb (IVA12), InVivoPure

InVivo Biotech

HLA DP/DQ/DR mAb (IVA12), InVivoPure

5

Neutralisation/Blocking

Research Use Only

Monoclonal

IVA12

1 mg/ml

>=90%

Liquid

Mouse

IgG1

The clone IVA12 recognizes the shared epitopes of human leukocyte antigen (HLA) class II molecules HLA-DP, HLA-DQ and HLA-DR heterodimeric cell surface glycoproteins comprised of an alpha (heavy) chain and a beta (light) chain. They are expressed on B cells, activated T cells, monocytes/macrophages, dendritic cells, and other non-professional antigen presenting cells (APCs). HLA-Class II expressing APCs specifically present antigens recognized by TCR/CD3 complex of CD4+ T cells. Reactive microglia and perivascular cells in multiple sclerosis lesions express all three types of HLA-Class II molecules, whereas microglia in the normal CNS express HLA-DR only.

Human

12352203