HLA-DQ Antibody (clone SPV-L3, Azide-free, BSA-free)
LS-C390300
ApplicationsFlow Cytometry, ImmunoFluorescence
Product group Antibodies
ReactivityHuman
Overview
- SupplierLifeSpan BioSciences
- Product NameHLA-DQ Antibody (clone SPV-L3, Azide-free, BSA-free)
- Delivery Days Customer23
- Antibody SpecificityHuman HLA-DQ
- Application Supplier NoteThe applications listed have been tested for the unmodified form of this product. Other forms have not been tested. Recognizes a DQ antigen, which is a dimer of 60kDa. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35kDa. It is encoded by 5 exons. exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Optimal dilution of the HLA-DQ antibody should be determined by the researcher.. Flo (0.5 - 1 µg/10E6 cells), IF (0.5 - 1 µg/ml) The applications listed have been tested for the unmodified form of this product. Other forms have not been tested. Recognizes a DQ antigen, which is a dimer of 60kDa. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35kDa. It is encoded by 5 exons. exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Optimal dilution of the HLA-DQ antibody should be determined by the researcher.
- ApplicationsFlow Cytometry, ImmunoFluorescence
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDSPV-L3
- Concentration1 mg/ml
- ConjugateUnconjugated
- Estimated Purity...
- HostMouse
- IsotypeIgG2a
- ReactivityHuman
- Storage Instruction-20°C
- UNSPSC12352203