HLA-DRB(L243), CF640R conjugate, 0.1mg/mL [26628-22-8]
BNC400458
ApplicationsFunctional Assay, Flow Cytometry, ImmunoPrecipitation, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
Product group Antibodies
ReactivityBovine, Canine, Human, Mammals, Monkey, Mouse, Primate
TargetHLA-DRB1
Overview
- SupplierBiotium
- Product NameHLA-DRB(L243), CF640R conjugate, 0.1mg/mL
- Delivery Days Customer9
- ApplicationsFunctional Assay, Flow Cytometry, ImmunoPrecipitation, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDL243
- Concentration0.1 mg/ml
- ConjugateOther Conjugate
- Gene ID3123
- Target nameHLA-DRB1
- Target descriptionmajor histocompatibility complex, class II, DR beta 1
- Target synonymsDRB1; HLA class II histocompatibility antigen, DR-1 beta chain; HLA-DR1B; HLA-DRB; human leucocyte antigen DRB1; lymphocyte antigen DRB1; major histocompatibility complex, class II, DR beta 1 precursor; MHC class II HLA-DR beta 1 chain; SS1
- HostMouse
- IsotypeIgG2a
- Protein IDP01911
- Protein NameHLA class II histocompatibility antigen, DRB1-15 beta chain
- Scientific DescriptionThis MAb reacts with the HLA-DRB1 antigen, a member of MHC class II molecules. It does not cross react with HLA-DP and HLA-DQ. It binds a conformational epitope on HLA-DR, which depends on the correct folding of the alpha/beta heterodimer. This MAb has been reported to block mixed lymphocyte reactions. The L243 antibody recognizes a different epitope than the LN3 monoclonal antibody, and these antibodies do not cross-block binding to each others respective epitopes. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36kD alpha (heavy) chain and a 28kD beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4 T cells. It is an excellent histiocytic marker in paraffin sections producing intense staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- SourceAnimal
- ReactivityBovine, Canine, Human, Mammals, Monkey, Mouse, Primate
- Storage Instruction2°C to 8°C
- UNSPSC12352203