HMGB1 Polyclonal Antibody

Elabscience

HMGB1 Polyclonal Antibody

12

ImmunoFluorescence, Western Blot, ImmunoHistoChemistry

Research Use Only

Polyclonal

1.45 mg/ml

Unconjugated

HMGB1

high mobility group box 1

HMG-1, HMG1, HMG3, SBP-1, high mobility group protein B1, Amphoterin, Sulfoglucuronyl carbohydrate binding protein, high-mobility group (nonhistone chromosomal) protein 1

Rabbit

IgG

High mobility group protein B1

High mobility group (HMG) proteins 1 and 2 are ubiquitous non-histone components of chromatin. Evidence suggests that the binding of HMG proteins to DNA induces alterations in the DNA architecture including DNA bending and unwinding of the helix. HMG proteins synergize with Oct-2, members of the NFB family, ATF-2 and c-Jun to activate transcription. Other studies indicate that phosphorylation of HMG protein is required to stimulate the transcriptional activity of the protein. Human HMG-1 and HMG-2 both contain two DNA-binding domains, termed HMG boxes. HMG proteins bind single-stranded DNA but induce conformational changes in double-stranded DNA alone.

-20°C

41116161