Western Blot Positive WB detected in: Hela whole cell lysate, MCF-7 whole cell lysate, HepG2 whole cell lysate, 293T whole cell lysate, 293 whole cell lysate, U87 whole cell lysate, SH-SY5Y whole cell lysate All lanes: HNRNPK antibody at 1.3microg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 51, 52, 49 KDa Observed band size: 60 KDa
Western Blot Positive WB detected in: Hela whole cell lysate, MCF-7 whole cell lysate, HepG2 whole cell lysate, 293T whole cell lysate, 293 whole cell lysate, U87 whole cell lysate, SH-SY5Y whole cell lysate All lanes: HNRNPK antibody at 1.3microg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 51, 52, 49 KDa Observed band size: 60 KDa
HNRNPK Recombinant Monoclonal Antibody
CSB-RA010611A0HU
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetHNRNPK
Overview
- SupplierCusabio
- Product NameHNRNPK Recombinant Monoclonal Antibody
- Delivery Days Customer20
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID3G7
- ConjugateUnconjugated
- Gene ID3190
- Target nameHNRNPK
- Target descriptionheterogeneous nuclear ribonucleoprotein K
- Target synonymsAUKS; CSBP; dC-stretch binding protein; heterogeneous nuclear ribonucleoprotein K; HNRPK; transformation upregulated nuclear protein; TUNP
- IsotypeIgG
- Protein IDP61978
- Protein NameHeterogeneous nuclear ribonucleoprotein K
- Scientific DescriptionOne of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest.
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC12352203