HPI-1 (hydrate) [1262770-72-8]

TargetMol Chemicals

HPI-1 (hydrate) [1262770-72-8]

999

1262770-72-8

Chemical

Research Use Only

HPI-1 (hydrate)

C27H31NO7

481.54

HPI-1 (hydrate) is a Hedgehog (Hh) pathway inhibitor that suppresses signaling through Sonic Hh (IC50= 1.5 microM) without significantly affecting Wnt signaling (IC50≥ 30 microM).1HPI-1 suppresses Hh activation induced by loss of Suppressor of Fused or by Gli overexpression, suggesting action at posttranslational modification of Gli protein or at the interaction of Gli with a co-factor.1HPI-1 (hydrate) also inhibits signaling through the oncogenic Smoothened (Smo) mutant SmoM2 in neuron precursors, preventing cell proliferation.1

3 years

O=C(OCCOC)C1=C(NC2=C(C(=O)CC(C=3C=CC=CC3OC)C2)C1C=4C=CC=C(O)C4)C.O

-20°C

12352200