Bio-Connect

HPK1-IN-54

HY-159905
MedChem Express
Product group Chemicals
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Overview

  • Supplier
    MedChem Express
  • Product Name
    HPK1-IN-54
  • Delivery Days Customer
    5
  • Certification
    Research Use Only
  • Scientific Description
    HPK1-IN-54 is a potent HPK1 (Hematopoietic Progenitor Kinase 1) inhibitor that enhances T cell activation and proliferation by inhibiting HPK1 activity, thereby exhibiting antitumor effects. Its IC 50 value against HPK1 is 2.67 nM, with excellent selectivity over the MAP4K family (>100-fold) and other selected kinases (>300-fold). HPK1-IN-54 displayed moderate in vivo clearance and reasonable oral exposure in mice and rats. Additionally, HPK1-IN-54 demonstrated strong antitumor efficacy in a CT26 murine colon cancer model and synergistic effects when combined with anti- PD-1 (HY-P9902A). HPK1-IN-54 shows promise for research in the field of immunotherapy [1] .
  • UNSPSC
    12352200