HPK1-IN-54
HY-159905
Product group Chemicals
Overview
- SupplierMedChem Express
- Product NameHPK1-IN-54
- Delivery Days Customer5
- CertificationResearch Use Only
- Scientific DescriptionHPK1-IN-54 is a potent HPK1 (Hematopoietic Progenitor Kinase 1) inhibitor that enhances T cell activation and proliferation by inhibiting HPK1 activity, thereby exhibiting antitumor effects. Its IC 50 value against HPK1 is 2.67 nM, with excellent selectivity over the MAP4K family (>100-fold) and other selected kinases (>300-fold). HPK1-IN-54 displayed moderate in vivo clearance and reasonable oral exposure in mice and rats. Additionally, HPK1-IN-54 demonstrated strong antitumor efficacy in a CT26 murine colon cancer model and synergistic effects when combined with anti- PD-1 (HY-P9902A). HPK1-IN-54 shows promise for research in the field of immunotherapy [1] .
- UNSPSC12352200