HS014

Biorbyt

HS014 [207678-81-7]

10

207678-81-7

Research Use Only

C71H94N20O17S2

1563.76

HS014 is a potent and selective melanocortin-4 (MC4) receptor antagonist, with Kis of 3.16, 108, 54.4 and 694 nM for human MC4, MC1, MC3 and MC5 receptors, respectively. HS014 modulates the behavioral effects of morphine in mice. HS014 increases food intake in free-feeding rats.

CC(N[C@H]1CSSC[C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@H](NC([C@@H](NC([C@@H](NC1=O)CCC(O)=O)=O)CC2=CN=CN2)=O)CC3=CC4=CC=CC=C4C=C3)=O)CCCNC(N)=N)=O)CC5=CNC6=CC=CC=C56)=O)=O)C(N7CCC[C@H]7C(N8CCC[C@H]8C(N[C@H](C(N[C@@H](C(N)=O)CC(O)=O)=O)CCCCN)=O)=O)=O)=O

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