HSD17B13-IN-42 [2770246-10-9]

TargetMol Chemicals

HSD17B13-IN-42 [2770246-10-9]

16

Research Use Only

C23H14Cl2F3N3O4

524.28

HSD17B13-IN-42 (compound 10) is a potent inhibitor of hydroxysteroid 17beta-dehydrogenase 13 (HSD17B13), with an IC50 of < 0.1 microM using estradiol as substrates. HSD17B13-IN-42 plays an important role in nonalcoholic fatty liver diseases (NAFLDs) including NASH (nonalcoholic steatohepatitis) [1].

N(C(=O)C1=CC(Cl)=C(O)C(Cl)=C1)C2=C3C(N=CN(CC4=CC(OC(F)(F)F)=CC=C4)C3=O)=CC=C2

-20°C

51202000