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HSP40-4 Polyclonal Antibody

RD75900A
Reddot Biotech
ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetDNAJA1
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Overview

  • Supplier
    Reddot Biotech
  • Product Name
    HSP40-4 Polyclonal Antibody
  • Delivery Days Customer
    5
  • Applications
    Western Blot, ELISA, ImmunoHistoChemistry
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.5 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID3301
  • Target name
    DNAJA1
  • Target description
    DnaJ heat shock protein family (Hsp40) member A1
  • Target synonyms
    DJ-2; DjA1; DnaJ (Hsp40) homolog, subfamily A, member 1; dnaJ homolog subfamily A member 1; dnaJ protein homolog 2; HDJ2; hDJ-2; heat shock 40 kDa protein 4; heat shock protein J2; heat shock protein, DNAJ-like 2; HSDJ; HSJ2; HSJ-2; HSPF4; human DnaJ protein 2; NEDD7; neural precursor cell expressed, developmentally down-regulated 7
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    DnaJ-like proteins interact with HSP 70 molecular chaperones and function to facilitate protein folding and mitochondrial protein import. HSP 40-4, also known as HDJ2, is the human DnaJ homolog that functions as a co-chaperone with a cysteine-rich zinc finger domain. The cellular redox enzyme thioredoxin interacts with HSP 40-4, and oxidation and reduction reversibly regulate HSP 40-4 function in response to the changing redox states of the cell. The zinc finger domain of HSP 40-4 may act as a redox sensor of chaperone-mediated protein-folding machinery, since HSP 40-4 inactivation leads to the oxidation of cysteine thiols and a simultaneous release of coordinated zinc. Loss of the HSP 40-4 protein may be linked to severe defects in spermatogenesis that involve aberrant androgen signaling.
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203