HSP40-4 Polyclonal Antibody

Reddot Biotech

HSP40-4 Polyclonal Antibody

5

Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

0.5 mg/ml

Unconjugated

DNAJA1

DnaJ heat shock protein family (Hsp40) member A1

DJ-2; DjA1; DnaJ (Hsp40) homolog, subfamily A, member 1; dnaJ homolog subfamily A member 1; dnaJ protein homolog 2; HDJ2; hDJ-2; heat shock 40 kDa protein 4; heat shock protein J2; heat shock protein, DNAJ-like 2; HSDJ; HSJ2; HSJ-2; HSPF4; human DnaJ protein 2; NEDD7; neural precursor cell expressed, developmentally down-regulated 7

Rabbit

IgG

DnaJ-like proteins interact with HSP 70 molecular chaperones and function to facilitate protein folding and mitochondrial protein import. HSP 40-4, also known as HDJ2, is the human DnaJ homolog that functions as a co-chaperone with a cysteine-rich zinc finger domain. The cellular redox enzyme thioredoxin interacts with HSP 40-4, and oxidation and reduction reversibly regulate HSP 40-4 function in response to the changing redox states of the cell. The zinc finger domain of HSP 40-4 may act as a redox sensor of chaperone-mediated protein-folding machinery, since HSP 40-4 inactivation leads to the oxidation of cysteine thiols and a simultaneous release of coordinated zinc. Loss of the HSP 40-4 protein may be linked to severe defects in spermatogenesis that involve aberrant androgen signaling.

Human, Mouse, Rat

-20°C

12352203