HSP90/mTOR-IN-1
HY-151137
Molecular Weight717.21
Product group Chemicals
Overview
- SupplierMedChem Express
- Product NameHSP90/mTOR-IN-1
- Delivery Days Customer10
- CertificationResearch Use Only
- Molecular FormulaC36H34ClFN6O5S
- Molecular Weight717.21
- Scientific DescriptionHSP90/mTOR-IN-1 is a potent and orally active Hsp90 and mTOR inhibitor with IC50 values of 69 nM and 29 nM, respectively. HSP90/mTOR-IN-1 suppresses the proliferation of SW780 cells through the over-activation of the PI3K/AKT/mTOR pathway. HSP90/mTOR-IN-1 induces apoptosis and autophagy via selective Hsp90 and mTOR inhibition. HSP90/mTOR-IN-1 also has considerable in vivo anti-tumor activity. HSP90/mTOR-IN-1 can be used for researching bladder cancer.
- SMILESClC1=CC(NC(NC2=CC=C(C=C2)C3=NC(N4CCOCC4)=C5C6=C(SC5=N3)CN(CC6)C(C7=CC(C(C)C)=C(C=C7O)O)=O)=O)=CC=C1F
- Storage InstructionSee Manual
- UNSPSC12352200