Human CA8 protein, His tag (active)

GeneTex

Human CA8 protein, His tag (active)

9

Specific activity is > 450 pmol/min/microg, and is defined as the amount of enzyme that hydrolyze 1.0 pmole of 4-nitrophenyl acetate to 4-nitrophenol per minute at pH 7.5 at 37C.

Functional Assay

Research Use Only

1 mg/ml

Unconjugated

CA8

carbonic anhydrase 8

CA-RP, CA-VIII, CALS, CAMRQ3, CARP, SCAR34, carbonic anhydrase-related protein, CA-related protein, carbonate dehydratase, carbonic anhydrase VIII, carbonic anhydrase-like sequence

Carbonic anhydrase-related protein

The protein encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form. Mutations in this gene are associated with cerebellar ataxia, mental retardation, and dysequilibrium syndrome 3 (CMARQ3). Polymorphisms in this gene are associated with osteoporosis, and overexpression of this gene in osteosarcoma cells suggests an oncogenic role. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

-20°C or -80°C,2°C to 8°C

41116100

Human