Human DHEA (sulfate form) ELISA Kit

Arigo Biolaboratories

Human DHEA (sulfate form) ELISA Kit

23

ELISA

0.002 microg/ml

1 h, 15 min

Research Use Only

Dehydroepiandrosterone (5-Androstene-3 beta-oL-17-one, Androstenolone, Dehydroisoandrosterone, Transdehydroandrosterone, DHEA) is a steroid hormone present in blood mostly in its sulfate form (DHEA-S). DHEA-S is a more specific product of the adrenals and measurements of this steroid are widely used in clinical practice. The clinical importance of plasma assays of DHEA-S is associated with the diagnosis of adrenal hyperplasia and differential diagnosis of hirsutism. Dehydroepiandrosterone sulfate (DHEA-SO4) is almost exclusively synthesized by the adrenal cortex, and it is the most abundant steroid hormone in the peripheral circulation. It is the main source of the urinary 17-ketosteroids. The metabolic clearance of DHEA-SO4 is slow, and it is converted mostly to oestrogens. The hormone has a maximum level from puberty until 20-30 years of age, then there is a gradual decrease in the blood DHEA-SO4 concentration mainly in the menopause of women. Although the physiological role of DHEA-SO4 is not well established the serum level of this steroid hormone has an informative pathophysiological value. 1. The serum DHEA-SO4 radioimmunoassay seems to be a reliable tool to assess adrenal androgen function and the glandular overproduction of androgens. 2. High DHEA-SO4 values indicate a virilizing disorder of adrenal origin in women. This includes mainly adrenal neoplasms or early or late onset of congenital adrenal hyperplasia. 3. Monitoring the DHEA-SO4 concentration may be useful to control the adrenal suppressive therapy (dexamethasone). 4. Low DHEA-SO4 levels can be an indicator of hormone-dependent immunological disorders. 5. Low levels of DHEA-SO4 may be related to the development of diseases that increases with age such as cancer and atherosclerosis. In these circumstances a systematically repeated assessment of the blood DHEA-SO4 values is recommended.

2°C to 8°C

41116133