Human DUSP10 protein, His tag (active)

GeneTex

Human DUSP10 protein, His tag (active)

9

Specific activity is > 600 units/mg, and is defined as the amount of enzyme that hydrolyze 1.0 nmole of p-nitrophenyl phosphate (pNPP) per minute at pH 7.5 at 37C.

Functional Assay

Research Use Only

0.25 mg/ml

Unconjugated

DUSP10

dual specificity phosphatase 10

MKP-5, MKP5, dual specificity protein phosphatase 10, dual specificity phosphatase MKP-5, map kinase phosphatase 5, mitogen-activated protein kinase phosphatase 5, serine/threonine specific protein phosphatase

Dual specificity protein phosphatase 10

Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

-20°C or -80°C,2°C to 8°C

41115809

Human