Human EREG Protein (ERE-HM201)
ERE-HM201
Protein IDO14944
Product group Proteins / Signaling Molecules
Overview
- SupplierKACTUS
- Product NameHuman EREG Protein (ERE-HM201)
- Delivery Days Customer9
- CertificationResearch Use Only
- Estimated Purity>95%
- Protein IDO14944
- Protein NameProepiregulin
- Scientific DescriptionEpidermal growth factor receptor (EGFR) regulates many crucial cellular programs, with seven different activating ligands shaping cell signaling in distinct ways.EGFR ligands epiregulin (EREG) and epigen (EPGN) stabilize different dimeric conformations of the EGFR extracellular region. As a consequence, EREG or EPGN induce less stable EGFR dimers than EGF-making them partial agonists of EGFR dimerization. Unexpectedly, this weakened dimerization elicits more sustained EGFR signaling than seen with EGF, provoking responses in breast cancer cells associated with differentiation rather than proliferation.
- Storage Instruction-20°C or -80°C,-80°C
- UNSPSC12352202