free sRANKL ELISA

Biomedica

Human FREE soluble RANKL ELISA

7

ELISA

ELISA

0.0625-2 pmol/l

intra-assay: 4%, inter-assay: 3%

serum, heparin plasma, EDTA plasma

0.01 pmol/l

human free unbound soluble RANKL

Sandwich ELISA

overnight assay

Assay

Research Use Only

Product Characteristics: The Biomedica human free, soluble, uncomplexed RANKL (TNFSF11) high sensitvity Sandwich ELISA kit is intended for the quantitative measurement of sRANKL levels in serum and heparin plama samples. The free sRANKL ELISA is highly recognised with >300 publications to date. Target Information: RANKL, the receptor activator of nuclear factor kappa B ligand, a member of the tumor necrosis factor (TNF) family, is the main stimulatory factor for the formation of mature osteoclasts and is essential for their survival. RANKL activates its specific receptor RANK, located on osteoclasts and dendritic cells. RANKL and its specific receptor RANK are not only key regulators of bone remodeling but also play an essential role in immunobiology, e.g. lymph node formation, establishment of the thymic microenviroment, mammary gland development during pregnancy, bone metastasis in cancer and sex-hormone, progestin-driven breast cancer, thermoregulation, and finally in the development of type 2 diabetes mellitus.

2-8°C

41116133