Human Frizzled-2 / FZD2 (24-190) Protein, Fc Tag

ACRObiosystems

Human Frizzled-2 / FZD2 (24-190) Protein, Fc Tag

4

Bio-Markers & CD Antigens

Research Use Only

Unconjugated

95%

Powder

44.4 kDa

Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 44.4 kDa. The protein migrates as 50-62 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. Description: Frizzled-2 (FZD2) is also known as FzE2, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD2 contains one FZ (frizzled) domain. FZD2 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. The Lys-Thr-X-X-X-Trp motif of FZD2 interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.

● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Human Frizzled-2, Fc Tag (FZ2-H5255) is expressed from human 293 cells (HEK293). It contains AA Gln 24 - Pro 190 (Accession # Q14332-1).

Human

Human

C-Fc. HEK293. Gln 24 - Pro 190

-20℃

12352202