Human HCC-1 protein
ORB107735
Product group Proteins / Signaling Molecules
Overview
- SupplierBiorbyt
- Product NameHuman HCC-1 protein
- Delivery Days Customer16
- Applications SupplierHPLC, SDS-PAGE
- CertificationResearch Use Only
- Estimated Purity>95%
- Scientific DescriptionHuman CCL14 is belonging to the CC chemokine family. It is encoded by the gene CCL14. CCL14 has two isoforms, CCL14a (HCC-1) and CCL14b (HCC-3). The sequence of HCC-3 differs from HCC-1 as follow: 27-27 R-QTGGKPKVVKIQLKLVG. CCL14 was first isolated from the hemofiltrate of human patients with chronic renal failure. The N-terminal processed forms HCC-1(3-74), HCC-1(4-74) and HCC-1(9-74) are produced in small amounts by proteolytic cleavage after secretion in blood. CCL14 promotes chemotaxis of T lymphocytes, monocytes and eosinophils, and inhibits infection of M tropic human immunodeficiency virus type 1 and is a ligand for CCR1, CCR3 and CCR5. Recombinant human CCL14 (66 a.a.) contains 66 amino acid residues and activation of the HCC 1/CCL14a precursor to active peptide is mediated by the urokinase type plasminogen activator or plasmin.
- SourceE.coli
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352202