Human Her2/ErbB2 Domain 4 Protein (HER-HM404)

KACTUS

Human Her2/ErbB2 Domain 4 Protein (HER-HM404)

9

Lyophilized

ErbB2, also called Neu and Her2 (human epidermal growth factor receptor 2), is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors. ErbB family members serve as receptors for the epidermal growth factor (EGF) family of growth factors.Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane.

-20°C or -80°C,-80°C

12352204