Human IL-2 R gamma / CD132 Protein, Fc Tag

ACRObiosystems

Human IL-2 R gamma / CD132 Protein, Fc Tag

4

Bio-Markers & CD Antigens

Research Use Only

Unconjugated

95%

Powder

53.5 kDa

Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 53.5 kDa. The protein migrates as 75-96 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. Description: IL-2R is a heterotrimeric protein binds and responds to the cytokine IL-2. Three distinct chains of IL-2R, termed as α, β and γ, which are non-covalently associated are identified. The α and β chains are involved in binding IL-2, while signal transduction following cytokine interaction is carried out by the γ chain, along with the β subunit. The α chain of the IL-2R can bind to the β chain before receptor interaction with IL-2. The γ chain alone has a very weak affinity for IL-2, but after the ligand is bound to the α/β heterodimer, the γ chain becomes recruited to the complex to form a very stable macromolecular quaternary ligand/receptor complex. Interleukin-2 receptor subunit gamma (IL2RG), also known as cytokine receptor common subunit gamma, CD antigen CD132, gammaC, p64, which belongs to the type I cytokine receptor family or type 5 subfamily. IL2RG is located on the surface of immature blood-forming cells in bone marrow. Defects in IL2RG are the cause of severe combined immunodeficiency X-linked T-cell-negative/B-cell-positive/NK-cell-negative (XSCID).

● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Human IL-2 R gamma, Fc Tag (ILG-H5256) is expressed from human 293 cells (HEK293). It contains AA Leu 23 - Asn 254 (Accession # AAH14972).

Human

Human

C-Fc. HEK293. Leu 23 - Asn 254

-20℃

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