Human IL13 R alpha 2 protein

Research Use Only
Product group Proteins / Signaling Molecules
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  • Product Name
    Human IL13 R alpha 2 protein
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    Research Use Only
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  • Scientific Description
    Interleukin-13 receptor subunit alpha-2 is also known as IL13Ralpha2, IL13Ra2 cluster of differentiation 213A2, CD213A2, CT19, IL-13R, IL13BP, and is a membrane bound protein that in humans is encoded by the IL13RA2 gene. IL13Ralpha2 is closely related to IL13Ralpha1, a subunit of the interleukin-13 receptor complex. This protein binds IL13 with high affinity, but lacks any significant cytoplasmic domain, and does not appear to function as a signal mediator. It is, however able to regulate the effects of both IL13 and IL4, despite the fact it is unable to bind directly to the latter. It is also reported to play a role in the internalization of IL13. IL13Ralpha2 is a component of the cell surface receptors, however, the majority exists in intracellular pools and in soluble form, and thus plays an opposite role as a potent IL13 antagonist compared with IL13Ralpha1. It also functions as an inhibitor of IL4-dependent pathway probably through the physical interaction between the short intracellular domain of and cytoplasmic domain of IL13Ralpha2 and the IL4Ralpha chain. In spite of the failed STAT signaling function, IL13Ralpha2 dose induce TGF-beta production and fibrosis. Additionally, IL13Ralpha2has been reported to be abundantly and specifically overexpressed in glioblastoma multiforme.
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