Human Kallikrein 5/KLK5 Protein (KLK-HM105)

KACTUS

Human Kallikrein 5/KLK5 Protein (KLK-HM105)

9

Research Use Only

>95%

Kallikrein-5

The inhibition of kallikrein 5 (KLK5) has been identified as a potential strategy for treatment of the genetic skin disorder Netherton syndrome, in which loss-of-function mutations in the SPINK5 gene lead to down-regulation of the endogenous inhibitor LEKTI-1 and profound skin-barrier defects with severe allergic manifestations. To aid in the development of a medicine for this target, an X-ray crystallographic system was developed to facilitate fragment-guided chemistry and knowledge-based drug-discovery approaches.

-20°C or -80°C,-80°C

12352202