Human LRRC32, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
Human LRRC32, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
Human LRRC32 / GARP / Garpin Protein, Fc Tag
LR2-H5256
Overview
- SupplierACRObiosystems
- Product NameHuman LRRC32 / GARP / Garpin Protein, Fc Tag
- Delivery Days Customer4
- Category SupplierBio-Markers & CD Antigens
- CertificationResearch Use Only
- ConjugateUnconjugated
- Estimated Purity95%
- FormatPowder
- Molecular Weight92.4 kDa
- Scientific DescriptionCharacteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 92.4 kDa. The protein migrates as 105 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. Description: Leucine-rich repeat protein 32 (LRRC32), also known as GARP (glycoprotein A repetitions predominant). LRRC32 expression promotes the acquisition of a Treg phenotype including reduced cellular proliferation, reduced cytokine secretion, and the capacity to suppress the proliferation of naïve T cells. LRRC32 binds directly to the TGF-beta latency associated peptide (LAP) and tethers latent TGF-beta on the surface of activated Treg cells. The presentation of TGF-beta on Tregs contributes to their ability to suppress naïve T cell proliferation.
- Shelf life instruction● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
- SourceHuman LRRC32, Fc Tag (LR2-H5256) is expressed from human 293 cells (HEK293). It contains AA His 20 - Asn 627 (Accession # Q14392-1).
- ReactivityHuman
- Reactivity SupplierHuman
- Reactivity Supplier NoteC-Fc. HEK293. His 20 - Asn 627
- Storage Instruction-20℃
- UNSPSC12352202