SDS-PAGE of GTX03561-pro human PTPN12 protein, His tag and GST tag (active).
Human PTPN12 protein, His tag and GST tag (active)
GTX03561-PRO
Product group Molecular Biology
Overview
- SupplierGeneTex
- Product NameHuman PTPN12 protein, His tag and GST tag (active)
- Delivery Days Customer9
- CertificationResearch Use Only
- ConjugateUnconjugated
- Scientific DescriptionThe protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
- Storage Instruction-20°C
- UNSPSC41116133