Bio-Connect

HUS1 Antibody, HRP conjugated

Research Use Only
CSB-PA010909LB01HU
Cusabio
ApplicationsELISA
Product group Antibodies
ReactivityHuman
TargetHUS1
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Overview

  • Supplier
    Cusabio
  • Product Name
    HUS1 Antibody, HRP conjugated
  • Delivery Days Customer
    20
  • Applications
    ELISA
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    HRP
  • Gene ID3364
  • Target name
    HUS1
  • Target description
    HUS1 checkpoint clamp component
  • Target synonyms
    checkpoint protein HUS1; hHUS1; HUS1 checkpoint homolog; hus1+-like protein
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDO60921
  • Protein Name
    Checkpoint protein HUS1
  • Scientific Description
    Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3\-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase.
  • Reactivity
    Human
  • Storage Instruction
    -20°C or -80°C
  • UNSPSC
    12352203