HX103
HY-152098
Molecular Weight602.04
Product group Chemicals
Overview
- SupplierMedChem Express
- Product NameHX103
- Delivery Days Customer10
- CertificationResearch Use Only
- Molecular FormulaC26H25ClFN7O5S
- Molecular Weight602.04
- Scientific DescriptionHX103 is an epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI)-based fluorogenic probe. HX103 inhibits EGFR 19 del, EGFR L858R, EGFR wild type and EGFR T790M with IC50s of 1.3, 1.5, 4.0 and 977 nM, respectively. HX103 can be used for quantifying active-EGFR to predict agent sensitivity in NSCLC patients with EGFR-activating mutations.
- SMILESCOC1=C(C=C2N=CN=C(C2=C1)NC3=CC(Cl)=C(C=C3)F)OCCCNC4=CC=C(C5=NON=C45)S(=O)(N(C)C)=O
- Storage InstructionSee Manual
- UNSPSC12352200