Hydralazine hydrochloride [304-20-1]

TargetMol Chemicals

Hydralazine hydrochloride

4

304-20-1

Chemical

Research Use Only

Hydralazine hydrochloride

99.10%

C8H9ClN4

196.64

Hydralazine hydrochloride (Apresoline) is the hydrochloride salt of hydralazine, a phthalazine derivative with antihypertensive and potential antineoplastic activities. Hydralazine alters intracellular calcium release and interferes with smooth muscle cell calcium influx, resulting in arterial vasodilatation. This agent also inhibits the phosphorylation of myosin protein and chelation of trace metals required for smooth muscle contraction, resulting in an increase in heart rate, stroke volume, and cardiac output. In addition to its cardiovascular effects, hydralazine inhibits DNA methyltransferase, which may result in inhibition of DNA methylation in tumor cells.

3 years

NNC1=NN=CC2=CC=CC=C12

-20°C

12352200