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Hydrastine

HY-B0927
MedChem Express
CAS Number118-08-1
DownloadMSDS
Product group Chemicals
Estimated Purity99.57
Molecular Weight383.39
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Hydrastine [118-08-1]
  • Delivery Days Customer
    10
  • CAS Number
    118-08-1
  • Certification
    Research Use Only
  • Estimated Purity
    99.57
  • Molecular Formula
    C21H21NO6
  • Molecular Weight
    383.39
  • Scientific Description
    Hydrastine ((-)-beta-Hydrastine; (1R,9S)-beta-Hydrastine) is a selective competitive inhibitor of tyrosine hydroxylase (TH), inhibiting dopamine biosynthesis (IC50=20.7 microM, PC12 cells). Hydrastine also inhibits the organic cation transporter OCT1 (IC50=6.6 microM). Hydrastine may cause neuronal toxicity through mitochondrial dysfunction rather than oxidative stress damage, and can aggravate cell apoptosis when combined with L-DOPA. Hydrastine can be used to study Parkinsons disease-related dopaminergic neuronal damage[1][2].
  • SMILES
    O=C1O[C@H]([C@@H]2N(C)CCC3=C2C=C(OCO4)C4=C3)C5=C1C(OC)=C(OC)C=C5
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

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