Hypidone (hydrochloride)

MedChem Express

Hypidone (hydrochloride) [1339058-04-6]

10

1339058-04-6

Research Use Only

99.73

C18H23ClN2O2

334.84

Hypidone hydrochloride (YL0919) is an orally active antidepressant agent with dual activity as a highly seletive 5-HT uptake blocker and an effective 5-HT 1A ?receptor agonist ( K i =0.19 nM). Hypidone hydrochloride inhibits the uptake of [ 3 H]-5-HT into rat cerebral cortical synaptosomes and HEK293 cells with IC 50 s of 1.78 nM and 1.93 nM, respectively. Hypidone hydrochloride shows remarkable antidepressant effects in animal models and has the poential for the investigation of depressive disorder [1] .

O=C1C=CC=CN1CC2(O)CCN(CC3=CC=CC=C3)CC2.[H]Cl

2°C to 8°C

12352200