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IC 86621

HY-100707
MedChem Express
CAS Number404009-40-1
DownloadMSDS
Product group Chemicals
Estimated Purity99.06
Molecular Weight221.256
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Overview

  • Supplier
    MedChem Express
  • Product Name
    IC 86621 [404009-40-1]
  • Delivery Days Customer
    5
  • CAS Number
    404009-40-1
  • Estimated Purity
    99.06
  • Molecular Formula
    C12H15NO3
  • Molecular Weight
    221.256
  • Scientific Description
    IC 86621 is a potent DNA-dependent protein kinase (DNA-PK) inhibitor, with an IC 50 of 120 nM. IC 86621 also acts as a selective and reversible ATP -competitive inhibitor.IC 86621 inhibits DNA-PK mediated cellular DNA double-strand break (DSB) repair ( EC 50 =68 microM). IC 86621 increases DSB-induced antitumor activity without cytotoxic effects. IC 86621 can protects rheumatoid arthritis (RA) T cells from apoptosis [1] [2] .
  • SMILES
    CC(C1=CC=C(N2CCOCC2)C=C1O)=O
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352200