IC 86621

MedChem Express

IC 86621 [404009-40-1]

5

404009-40-1

Research Use Only

99.06

C12H15NO3

221.256

IC 86621 is a potent DNA-dependent protein kinase (DNA-PK) inhibitor, with an IC50 of 120 nM. IC 86621 also acts as a selective and reversible ATP-competitive inhibitor.IC 86621 inhibits DNA-PK mediated cellular DNA double-strand break (DSB) repair (EC50=68 microM). IC 86621 increases DSB-induced antitumor activity without cytotoxic effects. IC 86621 can protects rheumatoid arthritis (RA) T cells from apoptosis[1][2].

CC(C1=CC=C(N2CCOCC2)C=C1O)=O

2°C to 8°C

12352200