ICA-105574

MedChem Express

ICA-105574 [316146-57-3]

10

316146-57-3

Research Use Only

99.25

C19H14N2O4

334.33

ICA-105574 is a potent and efficacious hERG channel activator. The primary mechanism by which ICA-105574 potentiates hERG channel activity is by removing hERG channel inactivation. ICA-105574 steeply potentiates current amplitudes more than 10-fold with an EC50 value of 0.5 +/- 0.1 microM and a Hill slope (n(H)) of 3.3 +/- 0.2[1].

O=C(NC1=CC=C(OC2=CC=CC=C2)C=C1)C3=CC=CC([N+]([O-])=O)=C3

-20°C,2°C to 8°C

12352200