Icotrokinra

MedChem Express

Icotrokinra

9

Research Use Only

99.89

Icotrokinra (JNJ-77242113) is an orally available, selective antagonist of the IL-23 receptor . Icotrokinra inhibits IL-23-induced STAT3 phosphorylation in peripheral blood mononuclear cells ( IC 50 =5.6 pM) and inhibits IL-23-induced interferon IFN-gamma production in NK cells with an IC 50 of 18.4 pM. In addition, Icotrokinra exhibits anti-inflammatory activity in a rat TNBS-induced colitis model. Icotrokinra can be used in the study of psoriasis, psoriatic arthritis, and inflammatory bowel disease [1] .

-20°C,-80°C

12352202