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ProductsBack/ID-8 [147591-46-6]
Chemical Structure
Chemical Structure
Chemical Structure

ID-8 [147591-46-6]

Research Use Only
AG-CR1-3655
AdipoGen Life Sciences
CAS Number147591-46-6
DownloadMSDS
Product group Chemicals
Estimated Purity>98%
Molecular Weight298.3
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    ID-8 [147591-46-6]
  • Delivery Days Customer
    10
  • CAS Number
    147591-46-6
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Molecular Formula
    C16H14N2O4
  • Molecular Weight
    298.3
  • Scientific Description
    Cell culture supplement that can sustain self-renewal and pluripotency of mouse embryonic stem cells (ESCs) in vitro. At 10microM it stimulates proliferation in serum-free media at a steady rate for more than 30 days. Reversibly maintains the long-term culture of ESCs by sustaining Nanog gene expression through Sox2-Oct3/4 activation and enhances Wnt-mediated hESC survival and proliferation via inhibition of DYRKs (DYRK2 and DYRK4). - Chemical. CAS: 147591-46-6. Formula: C16H14N2O4. MW: 298.3. Synthetic. Cell culture supplement that can sustain self-renewal and pluripotency of mouse embryonic stem cells (ESCs) in vitro. At 10microM it stimulates proliferation in serum-free media at a steady rate for more than 30 days. Reversibly maintains the long-term culture of ESCs by sustaining Nanog gene expression through Sox2-Oct3/4 activation and enhances Wnt-mediated hESC survival and proliferation via inhibition of DYRKs (DYRK2 and DYRK4).
  • SMILES
    CC1=C([N+]([O-])=O)C2=CC=C(O)C=C2N1C3=CC=C(OC)C=C3
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    51202000

References

  • Indole derivatives sustain embryonic stem cell self-renewal in long-term culture: T. Miyabayashi, et al.; Biosci. Biotechnol. Biochem. 72, 1242 (2008)
  • Wnt signaling orchestration with a small molecule DYRK inhibitor provides long-term xeno-free human pluripotent cell expansion: K. Hasegawa, et al.; Stem Cells Transl. Med. 1, 18 (2012)