IDH1 Inhibitor 2 [2244895-42-7]

MedChem Express

IDH1 Inhibitor 2 [2244895-42-7]

10

2244895-42-7

Research Use Only

99.40

C26H22N4O

406.48

IDH1 Inhibitor 2 (compound 13) is a potent wild-type IDH1 inhibitor that exerts its activity through covalent modification of His315 with an IC50 value of 110 nM. IDH1 Inhibitor 2 can dose-dependently reduce the intracellular reduced glutamine metabolic flux, thereby affecting cellular metabolic homeostasis. IDH1 Inhibitor 2 can be used to study the role of IDH1 in cellular metabolic regulation and cancer development[1][2].

N#CC1=C[C@@]2(C3=CC=CC=C3)[C@](CCC4=C2N=C(NC5=CC=CC=C5)N=C4)([H])[C@H](C)C1=O

-20°C,2°C to 8°C

12131703