Bio-Connect
IDH1(IDH1/1152), CF640R conjugate, 0.1mg/mL [26628-22-8]

IDH1(IDH1/1152), CF640R conjugate, 0.1mg/mL [26628-22-8]

BNC401152
Biotium
ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityBovine, Human, Mouse
TargetIDH1
Sign in to order and to see your custom pricing.
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    Biotium
  • Product Name
    IDH1(IDH1/1152), CF640R conjugate, 0.1mg/mL
  • Delivery Days Customer
    9
  • Applications
    ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    IDH1/1152
  • Concentration
    0.1 mg/ml
  • Conjugate
    Other Conjugate
  • Gene ID3417
  • Target name
    IDH1
  • Target description
    isocitrate dehydrogenase (NADP(+)) 1
  • Target synonyms
    epididymis luminal protein 216; epididymis secretory protein Li 26; epididymis secretory sperm binding protein; HEL-216; HEL-S-26; IDCD; IDH; IDP; IDPC; isocitrate dehydrogenase (NADP(+)) 1, cytosolic; isocitrate dehydrogenase [NADP] cytoplasmic; isocitrate dehydrogenase 1 (NADP+), soluble; NADP(+)-specific ICDH; NADP-dependent isocitrate dehydrogenase, cytosolic; NADP-dependent isocitrate dehydrogenase, peroxisomal; oxalosuccinate decarboxylase; PICD
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDO75874
  • Protein Name
    Isocitrate dehydrogenase [NADP] cytoplasmic
  • Scientific Description
    This antibody recognizes a 45 kDa protein, which is identified as isocitrate dehydrogenase (IDH1). It belongs to the isocitrate and isopropylmalate dehydrogenases family. IDH1 catalyzes the third step of the citric acid cycle, which involves the oxidative decarboxylation of isocitrate, forming alpha-ketoglutarate and CO2 in a two-step reaction. The first step involves the oxidation of isocitrate to the intermediate oxalosuccinate, while the second step involves the production of alpha-ketoglutarate. During this process, either NADH or NADPH is produced along with CO2. Recently, an inactivating mutation of IDH1 has been implicated in glioblastoma. IDH1 appears to function as a tumor suppressor that, when mutationally inactivated, contributes to tumorigenesis in part through induction of the HIF-1 pathway. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
  • Source
    Animal
  • Reactivity
    Bovine, Human, Mouse
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203