IFI35 Polyclonal Antibody

Reddot Biotech

IFI35 Polyclonal Antibody

5

Western Blot

Research Use Only

1 mg/ml

Unconjugated

IFI35

interferon induced protein 35

ifi-35; IFP 35; IFP35; interferon-induced 35 kDa protein

Rabbit

IgG

The Interferon family of proteins are able to alter the expression of a variety of target genes, thereby controlling various events within the cell. IFI-35 (Interferon-induced 35 kDa protein), also known as IFP35, is a 286 amino acid interferon-induced protein. Localized to the nucleus and expressed in macrophages, fibroblasts and epithelial cells, IFI-35 is a leucine zipper protein that can form homodimers, but, unlike most leucine zipper proteins, cannot bind DNA. Upon induction by IFN-Oe+/-, IFI-35 associates with Nmi (N-Myc-interacting protein), resulting in the formation of a high molecular weight complex that is thought to play a role in IFN-Oe+/- signaling and cellular responses. Once complexed with Nmi, IFI-35 is unable to be degraded by the proteasome, suggesting that IFI-35 is protected from degradation only when needed by IFN-Oe+/-. Two isoforms of IFI-35 exist due to alternative splicing events.

Human, Mouse

-20°C

12352203