IFN alpha-IFNAR-IN-1

MedChem Express

IFN alpha-IFNAR-IN-1 [844882-93-5]

10

844882-93-5

Research Use Only

C18H17NS

279.40

IFN alpha-IFNAR-IN-1 is a nonpeptidic, low-molecular-weight inhibitor of the interaction between IFN-alpha and IFNAR; inhibit MVA-induced IFN-alpha responses by BM-pDCs (IC50=2-8 uM). IC50 value: Target: IFN alpha-IFNAR interaction inhibitor IFN alpha-IFNAR-IN-1 specifically inhibits MVA-induced IFN-alpha responses by BM-pDCs. IFN alpha-IFNAR-IN-1 inhibited the IFN-alpha responses that were elicited after treatment with CpG2216, stimulation with poly(I:C), and infection with VSV-M2, whereas the total IL-12 production was notably less affected under those conditions. IFN alpha-IFNAR-IN-1 exerts immunosuppressive activity by the direct interaction with IFN-alpha [1].

CNCC1=CC=CC=C1SC2=C(C=CC=C3)C3=CC=C2

12352200