IFN-alpha/beta R2, Human (HEK293, His)

MedChem Express

IFN-alpha/beta R2, Human (HEK293, His)

10

Research Use Only

98.0

IFN-alpha/beta R2, one of the subunit of IFN-alpha/beta receptor, is a type I IFN receptor. IFN-alpha/beta R2 forms the heterodimeric receptor with IFNAR1, and binds to type I IFNs [1] . IFN-alpha/beta R2 also interacts with JAK1 and leads to tyrosine phosphorylation of the IFNARs and STAT proteins [2] . Upon activation by these IFNs, IFNAR1 and IFN-alpha/beta R2 undergo a conformational change to promote a cascade of downstream signaling events, including the phosphorylation of Tyk2 and JAK1, STAT1 and STAT2 [3] . IFN-alpha/beta R2 Protein, Human (HEK293, His) is a recombinant human IFN-alpha/beta R2 (I27-K243) with C-terminal 6*His tag, which is produced in HEK293 cells.

-20°C

12352202