IHC-plus(tm) CD74 / CLIP Antibody (clone CDLA74-1, Azide-free, BSA-free)

LifeSpan BioSciences

IHC-plus(tm) CD74 / CLIP Antibody (clone CDLA74-1, Azide-free, BSA-free)

14

Human CD74 / CLIP

The applications listed have been tested for the unmodified form of this product. Other forms have not been tested. CD74 associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [RefSeq] Titering of the CD74 antibody may be required for optimal performance. FFPE testing requires sections to be boiled in pH6 10mM citrate buffer for 10-20 minutes, followed by cooling at RT for 20 minutes, prior to staining. The CD74 antibody epitope is known to be extracellular.. Flo (0.5 - 1 µg/10E6 cells), IF (1 - 2 µg/ml), IHC-P (10 µg/ml) The applications listed have been tested for the unmodified form of this product. Other forms have not been tested. CD74 associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [RefSeq] Titering of the CD74 antibody may be required for optimal performance. FFPE testing requires sections to be boiled in pH6 10mM citrate buffer for 10-20 minutes, followed by cooling at RT for 20 minutes, prior to staining. The CD74 antibody epitope is known to be extracellular.

Flow Cytometry, ImmunoFluorescence, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

CDLA74-1

1 mg/ml

Unconjugated

...

CD74

CD74 molecule

CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated); CD74 molecule, major histocompatibility complex, class II invariant chain; DHLAG; gamma chain of class II antigens; HLA class II histocompatibility antigen gamma chain; HLADG; HLA-DR antigens-associated invariant chain; HLA-DR-gamma; Ia-associated invariant chain; Ia-GAMMA; II; MHC HLA-DR gamma chain; p33

Mouse

IgG1

Human

-20°C

12352203