IHC-plus(tm) DES / Desmin Antibody (clone D33)

LifeSpan BioSciences

IHC-plus(tm) DES / Desmin Antibody (clone D33)

14

The antibody D33 reacts exclusively with desmin, which is expressed in smooth and striated muscle cells and their tumors e. g. rhabdomyosarcoma and leiomyosarcoma in human, hamster, rat and chicken. The antibody does not cross react with vimentin or any o

Desmin is a 53 kD intermediate filament protein that exhibits a high degree of tissue specificity, its expression being predominantly confined to all types of muscle cells (cardiac, skeletal and smooth muscle). Regulation of desmin expression is stage and tissue-specific, since it is induced during terminal development. In skeletal en cardiac muscle cells desmin is localized in the Z-disk region and at the intercalated disk. The expression pattern of desmin in smooth muscle is much more heterogeneous. Coexpression of vimentin and desmin has been observed in tumors derived from muscle tissue, i. e. rhabdomyosarcomas and leiomyosarcomas. Furthermore, during myocard dysfunction dramatic changes in the distribution of desmin have been observed.. ICC, IHC, IHC-Fr, IHC-P (10 µg/ml), WB Desmin is a 53 kD intermediate filament protein that exhibits a high degree of tissue specificity, its expression being predominantly confined to all types of muscle cells (cardiac, skeletal and smooth muscle). Regulation of desmin expression is stage and tissue-specific, since it is induced during terminal development. In skeletal en cardiac muscle cells desmin is localized in the Z-disk region and at the intercalated disk. The expression pattern of desmin in smooth muscle is much more heterogeneous. Coexpression of vimentin and desmin has been observed in tumors derived from muscle tissue, i. e. rhabdomyosarcomas and leiomyosarcomas. Furthermore, during myocard dysfunction dramatic changes in the distribution of desmin have been observed.

Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

D33

Unconjugated

...

DES

desmin

cardiomyopathy, dilated 1F (autosomal dominant); CDCD3; CSM1; CSM2; desmin; epididymis secretory sperm binding protein; intermediate filament protein; LGMD1D; LGMD1E; LGMD2R

Mouse

IgG1

Bovine, Canine, Chicken, Equine, Hamster, Human, Porcine, Rat

-20°C,2°C to 8°C

12352203