IKBKG Antibody

Cusabio

IKBKG Antibody

20

Western Blot, ELISA

Research Use Only

Polyclonal

Unconjugated

IKBKG

inhibitor of nuclear factor kappa B kinase regulatory subunit gamma

AMCBX1, EDAID1, FIP-3, FIP3, Fip3p, IKK-gamma, IKKAP1, IKKG, IMD33, IP, IP1, IP2, IPD2, NEMO, SAIDX, ZC2HC9, NF-kappa-B essential modulator, 14.7K (adenovirus E3 protein) interacting protein 3, I-kappa-B kinase subunit gamma, NF-kappa-B essential modifier, ikB kinase subunit gamma, ikB kinase-associated protein 1, incontinentia pigmenti, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma, inhibitor of nuclear factor kappa B kinase subunit gamma

Rabbit

IgG

NF-kappa-B essential modulator

Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either Lys-63-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires Lys-27-linked polyubiquitination. Xiao G., Oncogene 19:5198-5203(2000). Hong X., FEBS Lett. 499:133-136(2001). Wu R.-C., Mol. Cell. Biol. 22:3549-3561(2002).

Human

-20°C or -80°C

41116161