IKZF1 antibody

Biorbyt

IKZF1 antibody

16

Western Blot

WB:1:1000-1:5000 WB

Research Use Only

Polyclonal

Unconjugated

IKZF1

IKAROS family zinc finger 1

CLL-associated antigen KW-6; CVID13; DNA-binding protein Ikaros; Hs.54452; IK1; IKAROS; ikaros family zinc finger protein 1; LYF1; LyF-1; lymphoid transcription factor LyF-1; PPP1R92; PRO0758; protein phosphatase 1, regulatory subunit 92; zinc finger protein, subfamily 1A, 1 (Ikaros); ZNFN1A1

Rabbit

DNA-binding protein Ikaros

Rabbit polyclonal to IKZF1.Ikaros family zinc finger protein 1 (IKZF1) is a transcription factor that belongs to the family of zincfingerDNA binding proteins associated with chromatin remodeling. The expression of IKZF1 isrestricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator oflymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoformshave been described for this gene. All isoforms share a common C-terminal domain, which containstwo zinc finger motifs required for hetero-or homodimerization and for interactions with other proteins.The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and thenuclear localization signal, resulting in members with and without DNA-binding properties. Only a fewisoforms display high affinity binding to a specific core DNA sequence element in the promoters oftarget genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and thought tofunction as dominant negative factors. Overexpression of some dominant-negative isoforms havebeen associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL).

Human

-20°C

12352203