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IL-23 (human) (rec.)

CHI-AG-40A-0038
Chimerigen Laboratories
Protein IDP29460
Product group Proteins / Signaling Molecules
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Overview

  • Supplier
    Chimerigen Laboratories
  • Product Name
    IL-23 (human) (rec.)
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Estimated Purity
    >90%
  • Protein IDP29460
  • Protein Name
    Interleukin-12 subunit beta
  • Scientific Description
    Interleukin-23 (IL-23) is a heterodimeric cytokine and a member of the IL-12 family involved in innate and adaptive immunity. It is composed of the IL-12 p40 chain covalently linked to p19, a chain related to the IL-12 p35 subunit. IL-23 signals through the IL-23 receptor complex, which is composed of the IL-12Rbeta1 chain and a gp130-like chain, IL-23R. Triggering of the IL-23 receptor complex leads to the activation of Tyk2, Jak2 and STAT1, 3 and 4. IL-23 induces IFN-gamma production, Th1 cell differentiation, and activation of the antigen-presenting functions of dendritic cells. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and important for tumorigenesis. - Protein. Human IL-12p40 peptide (aa 23-328) is fused at the C-terminus to a 18 aa linker peptide (GSTSGSGKPGSGEGSTKG) and to the IL-23p19 peptide (aa 20-189) and fused at the N-terminus to a FLAG®-tag. Source: HEK 293 cells. Endotoxin content: 90% (SDS-PAGE). Interleukin-23 (IL-23) is a heterodimeric cytokine and a member of the IL-12 family involved in innate and adaptive immunity. It is composed of the IL-12 p40 chain covalently linked to p19, a chain related to the IL-12 p35 subunit. IL-23 signals through the IL-23 receptor complex, which is composed of the IL-12Rbeta1 chain and a gp130-like chain, IL-23R. Triggering of the IL-23 receptor complex leads to the activation of Tyk2, Jak2 and STAT1, 3 and 4. IL-23 induces IFN-gamma production, Th1 cell differentiation, and activation of the antigen-presenting functions of dendritic cells. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and important for tumorigenesis.
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352202

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