IL-38 (human) (rec.) (His)

AdipoGen Life Sciences

IL-38 (human) (rec.) (His)

10

Research Use Only

>95%

IL1F10

interleukin 1 family member 10

FIL1-theta, FKSG75, IL-1HY2, IL-38, IL1-theta, IL1HY2, interleukin-1 family member 10, FIL1 theta, IL-1 theta, IL-1F10 (canonical form IL-1F10a), family of interleukin 1-theta, interleukin 1 family member 10 (theta), interleukin-1 HY2, interleukin-1 receptor antagonist FKSG75, interleukin-1 receptor antagonist-like FIL1 theta, interleukin-38

Interleukin-1 family member 10

IL-38 (IL-1F10) mRNA is expressed in heart, placenta, fetal liver, spleen, thymus and tonsil. The expression in a variety of immune tissues and similarity to IL-1Ra suggest a role of IL-1F10 in the inflammatory response. It has been reported that removal of the N-terminus domain of the interleukins of the IL-1F family such as IL-1F5 / 6 / 8 or 9 (also called IL-36Ra, IL-36alpha, IL-36beta or IL-36gamma) is important to increase their biological activity. Recently it has been shown that IL-38 is N-terminally processed and secreted by apoptotic cells. Released processed IL-38 (20-152) binds to the receptor Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1; TIGIRR-2) at the surface of macrophages. Processed IL-38-activated IL1RAPL1 reduces the production of IL-6 leading to inflammation attenuation. - Recombinant protein. Human IL-38 (aa 1-152) is fused at the C-terminus to a His-tag. Source: E. coli. Lyophilized. In 50mM TRIS-Cl, pH 8.0, containing 150mM NaCl. IL-38 (IL-1F10) mRNA is expressed in heart, placenta, fetal liver, spleen, thymus and tonsil. The expression in a variety of immune tissues and similarity to IL-1Ra suggest a role of IL-1F10 in the inflammatory response. It has been reported that removal of the N-terminus domain of the interleukins of the IL-1F family such as IL-1F5 / 6 / 8 or 9 (also called IL-36Ra, IL-36alpha, IL-36beta or IL-36gamma) is important to increase their biological activity. Recently it has been shown that IL-38 is N-terminally processed and secreted by apoptotic cells. Released processed IL-38 (20-152) binds to the receptor Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1; TIGIRR-2) at the surface of macrophages. Processed IL-38-activated IL1RAPL1 reduces the production of IL-6 leading to inflammation attenuation.

-20°C,2°C to 8°C

41116120

Human